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Dental Health and Dementia: More than Forgetfulness

Course Number: 566

Proposed Mechanisms of Interaction between Periodontal Disease and Dementia

Periodontitis has been linked to cognitive impairment and dementia after controlling for confounding factors such as age, sex, and educational attainment.4,18,20,62-65Periodontal disease progression is characterized by dysbiosis and elevated chronic inflammation, and dementia and Alzheimer’s Disease have been linked to periodontal disease through both inflammatory and bacterial mechanisms.20,27,28,66-71 Periodontitis has also been linked to increased systemic and neurological markers of Alzheimer’s disease.20,72,73