Reference: CR Goyal,1 JG Qaqish,1 T He,2 R Eusebio.2 1All Sum Research, Mississauga, Ontario, Canada. 2Procter & Gamble, Mason, OH USA.
To compare the anti-gingivitis efficacy of a stabilized stannous fluoride dentifrice versus a positive control triclosan dentifrice over a 2-month period.
- 0.454% stabilized stannous fluoride dentifrice
- Positive control dentifrice with triclosan and 0.24% sodium fluoride
Gingivitis, which typically results from poor plaque control, is characterized by gingival bleeding and inflammation. When formulated in a stabilized, bioavailable dentifrice, stannous fluoride inhibits gingivitis through bactericidal and bacteriostatic activity. Recent learnings show properly formulated stabilized stannous fluoride dentifrice also reduces gingivitis by binding to bacterial endotoxins in the gingival sulcus that trigger the inflammatory process. This mechanism results in less virulent plaque and decreased inflammation and bleeding. Findings from this clinical trial show that after 2 months of use, all subjects using the stannous fluoride dentifrice had a reduction in bleeding sites and virtually all (99%) had a reduction in their Lobene Modified Gingival Index score, an assessment of gingival inflammation. Based on these findings, dental professionals should consider recommending a stabilized stannous fluoride dentifrice, like Crest Gum Detoxify, to patients with gingivitis as well as those who are susceptible to the disease.