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The Oral Microbiome & Systemic Disease

Course Number: 561

References / Additional Resources

  1. Shiel WC. Medical Definition of Commensal. MedicineNet. 2018 Dec 21. Accessed June 18, 2019.

  2. Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014 Jul;16(7):1024-33. doi: 10.1111/cmi.12308. Epub 2014 Jun 2.

  3. Gene expression profiling. Wikipedia. 2018 Dec 15. Accessed June 18, 2019.

  4. NIH. US National Library of Medicine. What is a Genome? 2019 Jun 11. Accessed June 18, 2019.

  5. Yang J. The Human Microbiome Project: Extending the Definition of What Constitutes a Human. NIH National Human Genome Research Institute. 2012 Jul 16. Accessed June 18, 2019.

  6. Mayo Clinic. Prebiotics, probiotics and your health. 2019 May 21. Accessed June 18, 2019.

  7. Luan K, Narvekar A. Maintaining the Oral Microbiome. Dimensions of Dental Hygiene. 2019 March 01. Accessed June 18, 2019.

  8. NIH. US National Library of Medicine Genetics Home Reference. What is Precision Medicine? 2019 Jun 11. Accessed June 18, 2019.

  9. Expanded Human Oral Microbiome Database. The Forsythe Institute. Accessed June 18, 2019.

  10. Park OJ, Yi H, Jeon JH, et al. Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions. J Dent Res. 2015 Jul;94(7):921-7. doi: 10.1177/0022034515583531. Epub 2015 Apr 22.

  11. Cobb CM, Kelly PJ, Williams KB, et al. The oral microbiome and adverse pregnancy outcomes. Int J Womens Health. 2017 Aug 8;9:551-559. doi: 10.2147/IJWH.S142730. eCollection 2017.

  12. Costalonga M, Herzberg MC. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett. 2014 Dec;162(2 Pt A):22-38. doi: 10.1016/j.imlet.2014.08.017. Epub 2014 Nov 8.

  13. Papaioannou W, Gizani S, Haffajee AD, et al. The microbiota on different oral surfaces in healthy children. Oral Microbiol Immunol. 2009 Jun;24(3):183-9. doi: 10.1111/j.1399-302X.2008.00493.x.

  14. Jia G, Zhi A, Lai PFH, et al. The oral microbiota - a mechanistic role for systemic diseases. Br Dent J. 2018 Mar 23;224(6):447-455. doi: 10.1038/sj.bdj.2018.217.

  15. Sampaio-Maia B, Caldas IM, Pereira ML, et al. The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases. Adv Appl Microbiol. 2016;97:171-210. doi: 10.1016/bs.aambs.2016.08.002. Epub 2016 Sep 21.

  16. Naseribafrouei A, Hestad K, Avershina E, et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014 Aug;26(8):1155-62. doi: 10.1111/nmo.12378. Epub 2014 Jun 1.

  17. Davis CD. The Gut Microbiome and Its Role in Obesity. Nutr Today. 2016 Jul-Aug;51(4):167-174. doi: 10.1097/NT.0000000000000167.

  18. Wang BY, Kuramitsu HK. Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii. Appl Environ Microbiol. 2005 Jan;71(1):354-62. doi: 10.1128/AEM.71.1.354-362.2005.

  19. van 't Hof W, Veerman EC, Nieuw Amerongen AV, et al. Antimicrobial defense systems in saliva. Monogr Oral Sci. 2014;24:40-51. doi: 10.1159/000358783. Epub 2014 May 23.

  20. Devine DA, Marsh PD, Meade J. Modulation of host responses by oral commensal bacteria. J Oral Microbiol. 2015 Feb 6;7:26941. doi: 10.3402/jom.v7.26941. eCollection 2015.

  21. Kilian M, Chapple IL, Hannig M, et al. The oral microbiome - an update for oral healthcare professionals. Br Dent J. 2016 Nov 18;221(10):657-666. doi: 10.1038/sj.bdj.2016.865.

  22. Meyle J, Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000. 2015 Oct;69(1):7-17. doi: 10.1111/prd.12104.

  23. Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010 Jul;8(7):481-90. doi: 10.1038/nrmicro2337.

  24. Gao L, Xu T, Huang G, et al. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell. 2018 May;9(5):488-500. doi: 10.1007/s13238-018-0548-1. Epub 2018 May 7.

  25. Han YW, Wang X. Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res. 2013 Jun;92(6):485-91. doi: 10.1177/0022034513487559. Epub 2013 Apr 26.

  26. Jeffcoat MK, Jeffcoat RL, Gladowski PA, et al. Impact of periodontal therapy on general health: evidence from insurance data for five systemic conditions. Am J Prev Med. 2014 Aug;47(2):166-74. doi: 10.1016/j.amepre.2014.04.001. Epub 2014 Jun 18.

  27. Kapil V, Haydar SM, Pearl V, et al. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med. 2013 Feb;55:93-100. doi: 10.1016/j.freeradbiomed.2012.11.013. Epub 2012 Nov 23.

  28. American Heart Association. More than 100 million Americans have high blood pressure, AHA says. 2018 Jan 31. Accessed June 18, 2019.

  29. He J, Li Y, Cao Y, et al. The oral microbiome diversity and its relation to human diseases. Folia Microbiol (Praha). 2015 Jan;60(1):69-80. doi: 10.1007/s12223-014-0342-2. Epub 2014 Aug 23.

  30. Zarco MF, Vess TJ, Ginsburg GS. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis. 2012 Mar;18(2):109-20. doi: 10.1111/j.1601-0825.2011.01851.x. Epub 2011 Sep 9.

  31. Ammann TW, Gmür R, Thurnheer T. Advancement of the 10-species subgingival Zurich biofilm model by examining different nutritional conditions and defining the structure of the in vitro biofilms. BMC Microbiol. 2012 Oct 5;12:227. doi: 10.1186/1471-2180-12-227.

  32. Monsarrat P, Blaizot A, Kémoun P, et al. Clinical research activity in periodontal medicine: a systematic mapping of trial registers. J Clin Periodontol. 2016 May;43(5):390-400. doi: 10.1111/jcpe.12534. Epub 2016 Apr 13.

  33. Martin-Cabezas R, Seelam N, Petit C, et al. Association between periodontitis and arterial hypertension: A systematic review and meta-analysis. Am Heart J. 2016 Oct;180:98-112. doi: 10.1016/j.ahj.2016.07.018. Epub 2016 Aug 8.

  34. Lira-Junior R, Åkerman S, Klinge B, et al. Salivary microbial profiles in relation to age, periodontal, and systemic diseases. PLoS One. 2018 Mar 14;13(3):e0189374. doi: 10.1371/journal.pone.0189374. eCollection 2018.

  35. Sfyroeras GS, Roussas N, Saleptsis VG, et al. Association between periodontal disease and stroke. J Vasc Surg. 2012 Apr;55(4):1178-84. doi: 10.1016/j.jvs.2011.10.008. Epub 2012 Jan 14.

  36. ADA. Dentists: Doctors of Oral Health. Accessed June 18, 2019.

  37. Shutoff K, Boyd L. Caring for patients with diabetes. Dimensions of Dental Hygiene. April 2018;16(4):40-43. Accessed June 18, 2019.

  38. CDC. Diagnosed Diabetes. Accessed June 18, 2019.

  39. Herman WH, Taylor GW, Jacobson JJ, et al. Screening for prediabetes and type 2 diabetes in dental offices. J Public Health Dent. 2015 Summer;75(3):175-82. doi: 10.1111/jphd.12082. Epub 2015 Feb 6.

  40. Bullon P, Newman HN, Battino M. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol 2000. 2014 Feb;64(1):139-53. doi: 10.1111/j.1600-0757.2012.00455.x.

  41. Geisinger ML, Michalowicz BS, Hou W, et al. Systemic Inflammatory Biomarkers and Their Association With Periodontal and Diabetes-Related Factors in the Diabetes and Periodontal Therapy Trial, A Randomized Controlled Trial. J Periodontol. 2016 Aug;87(8):900-13. doi: 10.1902/jop.2016.150727. Epub 2016 Apr 25.

  42. Mealey BL, Oates TW, American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J Periodontol. 2006 Aug;77(8):1289-303.

  43. American Heart Association. What is Cardiovascular Disease? 2017 May 31. Accessed June 18, 2019.

  44. Bahekar AA, Singh S, Saha S, et al. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J. 2007 Nov;154(5):830-7. Epub 2007 Aug 20. doi: 10.1016/j.ahj.2007.06.037.

  45. Liccardo D, Cannavo A, Spagnuolo G, et al. Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease. Int J Mol Sci. 2019 Mar 20;20(6). pii: E1414. doi: 10.3390/ijms20061414.

  46. Shi Q, Zhang B, Huo N, et al. Association between Myocardial Infarction and Periodontitis: A Meta-Analysis of Case-Control Studies. Front Physiol. 2016 Nov 4;7:519. eCollection 2016. doi: 10.3389/fphys.2016.00519.

  47. Dietrich T, Sharma P, Walter C, et al. The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease. J Clin Periodontol. 2013 Apr;40 Suppl 14:S70-84. doi: 10.1111/jcpe.12062.

  48. Kawabata Y, Ekuni D, Miyai H, et al. Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study. Am J Hypertens. 2016 Mar;29(3):388-96. doi: 10.1093/ajh/hpv117. Epub 2015 Jul 23.

  49. WHO. Global Health Observatory (GHO) data. Blood Pressure. Accessed June 18, 2019.

  50. Muntner P, Carey RM, Gidding S, et al. Potential US Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline. Circulation. 2018 Jan 9;137(2):109-118. doi: 10.1161/CIRCULATIONAHA.117.032582. Epub 2017 Nov 13.

  51. Martin-Cabezas R, Seelam N, Petit C, et al. Association between periodontitis and arterial hypertension: A systematic review and meta-analysis. Am Heart J. 2016 Oct;180:98-112. doi: 10.1016/j.ahj.2016.07.018. Epub 2016 Aug 8.

  52. Wan Majdiah WM, Siti Norsuryani S, Azelinda A, et al. Hypertension and its association with periodontal parameters in chronic periodontitis. Health and the Environment Journal. 2017;8(1):1-9. Accessed June 18, 2019.

  53. Gordon JH, LaMonte MJ, Genco RJ, et al. Association of clinical measures of periodontal disease with blood pressure and hypertension among postmenopausal women. J Periodontol. 2018 Oct;89(10):1193-1202. doi: 10.1002/JPER.17-0562. Epub 2018 Aug 15.

  54. American Heart Association. Ischemic Stroke (Clots). Accessed June 18, 2019.

  55. Khaku AS, Hegazy M, Tadi P. Cerebrovascular Disease (Stroke) [Updated 2019 May 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan.

  56. Tonomura S, Ihara M, Kawano T, et al. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Sci Rep. 2016 Feb 5;6:20074. doi: 10.1038/srep20074.

  57. Gao Y, Wang Z, Qiao X, et al. Relationship between Moderate-Severe Periodontitis and Ischemic Stroke. NeuroQuantology. 2018 Jun 24;16(6). Accessed June 18, 2019.

  58. Inenaga C, Hokamura K, Nakano K, et al. A Potential New Risk Factor for Stroke: Streptococcus Mutans With Collagen-Binding Protein. World Neurosurg. 2018 May;113:e77-e81. doi: 10.1016/j.wneu.2018.01.158. Epub 2018 Feb 6.

  59. Conover J, Tolle S, Newcomb L. The relationship between obesity and periodontal disease. Dimensions of Dental Hygiene. May 2018;16(5):54-57. Accessed June 18, 2019.

  60. Khader YS, Bawadi HA, Haroun TF, et al. The association between periodontal disease and obesity among adults in Jordan. J Clin Periodontol. 2009 Jan;36(1):18-24. doi: 10.1111/j.1600-051X.2008.01345.x. Epub 2008 Nov 19.

  61. Sales-Peres SH, de Moura-Grec PG, Yamashita JM, et al. Periodontal status and pathogenic bacteria after gastric bypass: a cohort study. J Clin Periodontol. 2015 Jun;42(6):530-6. doi: 10.1111/jcpe.12410. Epub 2015 May 28.

  62. https://files.cdha.ca/Corporate/Colgate_Whole_Mouth_Health_Whitepaper_May2019.pdf[Colgate. Whole Mouth Health: The Next Generation of Everyday Prevention for Oral Health. 2018.](62. ) Accessed June 18, 2019.

  63. Hood L, Flores M. A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. N Biotechnol. 2012 Sep 15;29(6):613-24. doi: 10.1016/j.nbt.2012.03.004. Epub 2012 Mar 18.

  64. WHO. Cardiovascular diseases (CVDs). 2017 May 17. Accessed June 18, 2019.